AN301920L
Recombinant DDB2 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301920L
- Additional Names:
- DDB,UV-DDB,DDB2,DDBB,UV-DDB2,XPE
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human DDB2 fragment
- Clone:
- A636
- Uniprot:
- Q92466
- Synonyms:
- damage-specific DNA binding protein 2, 48kDa;Damage-specific DNA-binding protein 2;DDB p48 subunit;DDBB;DNA damage-binding protein 2;UV-damaged DNA-binding protein 2;UV-DDB 2;UV-DDB2;xeroderma pigmentosum group E protein;XPE
- Extra Details:
- Damaged DNA-Binding Protein (DDB) consists of a 127 kDa subunit (DDB-1) and a 48 kDa subunit (DDB-2) that contribute to the formation of the UV-damaged DNA-binding protein complex (UV-DDB). In conjunction with CUL4A and ROC-1, the UV-DDB complex forms an E3 ubiquitin ligase that recognizes a broad spectrum of DNA lesions such as cyclobutane pyrimidine dimers, 6-4 photoproducts, apurinic sites and short mismatches. The complex polyubiquitinates components of the nucleotide excision repair pathway. Loss of DDB activity has been identified in a subset of xeroderma pigmentosum complementation group E (XP-E) patients and has been linked to the deficient repair of cyclobutane pyrimidine dimers in cells derived from these patients.
- Shipping Conditions:
- Blue Ice