AN301906L
Recombinant CPS1 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301906L
- Additional Names:
- CPS,carbamoyl-phosphate synthase,CPSASE,CPS1,CPSASE1,PHN,carbamoyl-phosphate synthase 1,carbamoyl-phosphate synthase 1,CPSASE1,PHN,Carbamoyl phosphate synthase,Carbamoyl phosphate synthase [ammonia],Carbamoyl phosphate synthase [ammonia] mitochondrial,Carbamoyl phosphate synthetase 1,Carbamoyl phosphate synthetase 1 mitochondrial,Carbamoyl phosphate synthetase I,Carbamoylphosphate synthase,Carbamoyl-phosphate synthase [ammonia],Carbamoylphosphate synthetase 1,Carbamoylphosphate synthetase
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human CPS1 fragment
- Clone:
- A622
- Uniprot:
- P31327
- Synonyms:
- carbamoyl-phosphate synthase (ammonia);carbamoyl-phosphate synthase [ammonia], mitochondrial;carbamoyl-phosphate synthase 1, mitochondrial;Carbamoyl-phosphate synthetase I;carbamoylphosphate synthetase I;CPSASE1;GATD6;PHN
- Extra Details:
- Carbamoyl phosphate synthetase 1 (CPS1), a rate-limiting enzyme in the urea cycle, catalyzes the conversion of ammonia and bicarbonate to carbamoyl phosphate in mitochondria. Non-small cell lung carcinoma (NSCLC) cells with oncogenic KRAS and loss of the tumor suppressor LKB1 express CPS1 and depend on this enzyme for growth. CPS1 maintains pyrimidine/purine balance in these cancer cells. Silencing CPS1 reduces the pyrimidine to purine ratio and stalls DNA synthesis, leading to DNA damage and cancer cell death. In addition, the tumor suppressor p53 represses the expression of urea cycle enzymes CPS1, OTC, and ARG1 and, therefore, causes the accumulation of ammonia, suppressing cancer growth. Furthermore, research studies suggest that hypermethylation-mediated downregulation of CPS1 expression may contribute to the progression of normal hepatocytes to hepatocellular carcinoma (HCC).
- Shipping Conditions:
- Blue Ice