AN301902L
Recombinant TGF beta 1 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301902L
- Additional Names:
- DPD,Transforming growth factor beta,TGF-B,TGFB1,CED,DPD1,LAP,TGFB,TGFbeta,TGF-B Beta,Cartilage-inducing factor,Differentiation inhibiting factor,IBDIMDE,TGF-B1,TGF-beta 1,TGF-beta-1,TGF-B Beta1,Transforming growth factor beta-1 proprotein,Latency-associated peptide,Transforming growth factor beta-1,beta 1,Prepro transforming growth factor beta 1,TGF beta,TGF beta 1,TGF beta 1 protein,Tgfb-1,TGF-beta 1 protein,TGFbeta1,TGF-beta1,TGF-beta-5,transforming growth factor,Transforming Growth Factor
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human TGF beta 1 fragment
- Clone:
- A618
- Uniprot:
- P01137
- Synonyms:
- CED;DPD1;IBDIMDE;LAP;latency-associated peptide;prepro-transforming growth factor beta-1;TGF-beta-1;TGF-beta1;TGFB;TGFbeta;transforming growth factor beta-1 proprotein;transforming growth factor beta1
- Extra Details:
- Transforming growth factor-B Beta (TGF-B Beta) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis. TGF-B Beta elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases. The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-B Beta with high affinity but lacks a cytoplasmic signaling domain. Expression of the type III receptor can regulate TGF-B Beta signaling through presentation of the ligand to the signaling complex. The only known direct TGF-B Beta signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription.
- Shipping Conditions:
- Blue Ice