AN301896L
Recombinant Gelsolin Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301896L
- Additional Names:
- DKFZp313L,GSN,ADF,AGEL,gelsolin,Actin depolymerizing factor,DKFZp313L0718,Brevin,GELS,Actin-depolymerizing factor,Actin-depolymerizing factor,ADF,AGEL,Brevin,GELS,GSN
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human Gelsolin fragment
- Clone:
- A612
- Uniprot:
- P06396
- Synonyms:
- actin-depolymerizing factor;ADF;AGEL;brevin;epididymis secretory sperm binding protein;gelsolin
- Extra Details:
- Gelsolin also named as actin-depolymerizing factor, ADF, AGEL or Brevin, is an 83 kDa protein that shares structural and functional homology to villin and adseverin/scinderin. Gelsolin plays an important role in actin filament assembly by capping and severing actin proteins in a Ca2+-dependent manner. Gelsolin is important for cellular events (e.g., membrane ruffling, chemotaxis, ciliogenesis) that require cytoskeletal remodeling. Accordingly, cells from gelsolin knockout mice exhibit motility defects, including a failure to ruffle in response to growth factor stimulation. In humans, defects in gelsolin have been linked to amyloidosis type 5 (AMYL5), a hereditary disease characterized by cranial neuropathy, which appears to result from gelsolin amyloid deposition.
- Shipping Conditions:
- Blue Ice