Recombinant TFF1/pS2 Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301892L
Additional Names:: TFF,pNR,HPS,D21S,Protein Ps,Trefoil factor,TFF1,BCEI,D21S21,HP1.A,HPS2,pNR-2,pS2,Breast cancer estrogen-inducible protein,Polypeptide P1.A,Protein Ps2,Trefoil factor 1
Application:: IHC, WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human TFF1/pS2 fragment
Clone:: A608
Uniprot:: P04155
Synonyms:: BCEI;breast cancer estrogen-inducible protein;breast cancer estrogen-inducible sequence;D21S21;gastrointestinal trefoil protein pS2;HP1.A;HPS2;pNR-2;polypeptide P1.A;protein pS2;pS2;trefoil factor 1
Extra Details:: TFF1/pS2 is a gastric peptide that is highly expressed by mucosal goblet cells of the stomach, where it is thought to play a role in maintaining the integrity of the epithelial layer of the mucosa through the regulation of cell-cell adhesion and cell migration. Research studies have shown that TFF1 functions as a tumor suppressor in the stomach as its expression is frequently lost in gastric carcinomas, largely due to promoter hypermethylation. Research studies have also demonstrated that TFF1 is a transcriptional target of estrogen receptor-A Alpha and that TFF1 expression in breast carcinoma may be used as a predictive biomarker for response to anti-estrogen therapy.