AN301883L
Recombinant Cdc25C Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301883L
- Additional Names:
- CDC,PPP1R,CDC25C,CDC25,PPP1R60
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human Cdc25C fragment
- Clone:
- A595
- Uniprot:
- P30307
- Synonyms:
- CDC25;CDC25 homolog C;dual specificity phosphatase CDC25C;M-phase inducer phosphatase 3;mitosis inducer CDC25;phosphotyrosine phosphatase;PPP1R60;protein phosphatase 1, regulatory subunit 60
- Extra Details:
- Cdc25C is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis. Cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint. When phosphorylated at Ser216, Cdc25C binds to members of the 14-3-3 family of proteins, sequestering Cdc25C in the cytoplasm and thereby preventing premature mitosis. The checkpoint kinases Chk1 and Chk2 phosphorylate Cdc25C at Ser216 in response to DNA damage.
- Shipping Conditions:
- Blue Ice