Recombinant B7-H4 Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301876L
Additional Names:: B7S,PRO,UNQ,VTCN,B7-H,VCTN,B7h,VTCN1,B7-H4,B7H4,B7S1,B7X,B7h.5,PRO1291,VCTN1,UNQ659,B7H4T-cell costimulatory molecule B7x,B7S1VCTN1,B7XPRO1291,FLJ22418,Immune costimulatory protein B7-H4,Protein B7S1,T cell costimulatory molecule B7x,V-set domain containing T cell activation inhibitor 1,V-set domain-containing T-cell activation inhibitor 1
Application:: WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human B7-H4 fragment
Clone:: A588
Uniprot:: Q7Z7D3
Synonyms:: B7 family member, H4;B7 homolog 4;B7 superfamily member 1;B7-H4;B7h.5;B7H4;B7S1;B7X;immune costimulatory protein B7-H4;PRO1291;Protein B7S1;T cell costimulatory molecule B7x;T-cell costimulatory molecule B7x;V-set domain-containing T-cell activation inhibitor 1;VCTN1
Extra Details:: B7 homolog 4 (B7-H4), also known as VTCN1, is a member of the B7 family of cell surface ligands that regulate T cell activation and immune responses. B7-H4 protein contains two extracellular Ig-like V-type domains, a transmembrane domain, and a short, two amino acid intracellular domain. The B7-H4 protein is shown to inhibit T cell activation, proliferation, and cytokine production. Although B7-H4 mRNA is widely expressed, B7-H4 protein is restricted to antigen presenting cells and B cells. The B7-H4 protein is also found in several tumor types, including ovarian cancer and breast cancer. Research studies indicate that B7-H4 protein is present on the surface of ovarian tumor cells, and that targeted inhibition of B7-H4 using recombinant antibodies restores T cell activation pathways. These studies suggest some potential therapeutic value in blocking B7-H4 function and restoring T cell function in cancer patients.

Shipping Conditions:: Blue Ice