AN301873L
Recombinant Neutrophil Elastase Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301873L
- Additional Names:
- SCN,ELA,Elastase,ELANE,ELA2,GE,HLE,HNE,NE,PMN-E,SCN1,Elastase-2,Medullasin,Neutrophil elastase,Bone marrow serine protease,Human leukocyte elastase,PMN elastase,Elastase 2,Elastase 2 neutrophil,Elastase neutrophil expressed,ELNE,Granulocyte derived elastase,Leukocyte elastase,Neutrophil expressed,PMN E,Polymorphonuclear elastase
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human Neutrophil Elastase fragment
- Clone:
- A585
- Uniprot:
- P08246
- Synonyms:
- bone marrow serine protease;ELA2;elastase 2, neutrophil;elastase-2;GE;granulocyte-derived elastase;HLE;HNE;Human leukocyte elastase;leukocyte elastase;medullasin;NE;neutrophil elastase;PMN elastase;PMN-E;polymorphonuclear elastase;polymorphonuclear leukocyte elastase;SCN1
- Extra Details:
- Neutrophil Elastase is hematopoietic serine protease that belongs to the chymotrypsin superfamily and plays a critical role in the innate immune function of mature neutrophils and monocytes. Neutrophil elastase is actively synthesized as an inactive zymogen in myelocytic precursor cells of the bone marrow, which then undergoes activation by limited proteolysis and sorting to primary (azurophil) storage granules of mature neutrophil granulocytes for regulated release. Research studies have shown that neutrophils play a significant role in mediating the inflammatory response through the release of neutrophil elastase, which activates pro-inflammatory cytokines and degrades components of the extracellular matrix and Gram-negative bacteria. Mutations in the gene encoding neutrophil elastase, ELA2, have been implicated in hematological diseases such as cyclic and severe congenital neutropenia, which is characterized by defects in promyelocyte maturation.
- Shipping Conditions:
- Blue Ice