Recombinant ATF1 Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301850L
Additional Names:: ATF,Atf1
Application:: Flow Cytometry, IHC, WB, IF
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human ATF1 fragment
Clone:: A562
Uniprot:: P81269
Synonyms:: Activating transcription factor 1;cAMP-dependent transcription factor ATF-1;cyclic AMP-dependent transcription factor ATF-1;TCR-ATF1
Extra Details:: ATF-1 is a bZIP transcription factor that is a member of the cyclic AMP (cAMP)-response element-binding protein (CREB) family. Like other members of the CREB family, ATF-1 mediates signals from numerous physiological stimuli and activates target genes through cAMP-response elements, resulting in the regulation of a broad array of cellular responses. ATF-1 can be phosphorylated at Ser63 by protein kinase A (PKA), calmodulin-dependent protein kinase (CaMK), and cyclin-dependent kinase 3 (CDK3), which recruits CBP/p300 and enhances transcriptional activity. ATF-1 expression levels have been found to be elevated in lymphomas and metastatic melanoma cells, where it contributes to tumor growth.