AN301827L
Recombinant ErbB3/HER3 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301827L
- Additional Names:
- HER,LCCS,Proto-oncogene-like protein c-ErbB,Tyrosine kinase-type cell surface receptor HER,MDA-BF,p180-ErbB,p45-sErbB,p85-sErbB,ERBB3,ErbB-3,HER3,LCCS2,MDA-BF-1,c-erbB-3,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3,Proto-oncogene-like protein c-ErbB-3,Tyrosine kinase-type cell surface receptor HER3,EEBB3
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human ErbB3 / HER3 fragment
- Clone:
- A539
- Uniprot:
- P21860
- Synonyms:
- c-erbB-3;c-erbB3;ErbB-3;erbB3-S;FERLK;HER3;human epidermal growth factor receptor 3;LCCS2;MDA-BF-1;p180-ErbB3;p45-sErbB3;p85-sErbB3;proto-oncogene-like protein c-ErbB-3;receptor tyrosine-protein kinase erbB-3;tyrosine kinase-type cell surface receptor HER3;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3;VSCN1
- Extra Details:
- HER3/ErbB3 is a member of the ErbB receptor protein tyrosine kinase family, but it lacks tyrosine kinase activity. Tyrosine phosphorylation of ErbB3 depends on its association with other ErbB tyrosine kinases. Upon ligand binding, heterodimers form between ErbB3 and other ErbB proteins, and ErbB3 is phosphorylated on tyrosine residues by the activated ErbB kinase. There are at least 9 potential tyrosine phosphorylation sites in the carboxy-terminal tail of ErbB3. These sites serve as consensus binding sites for signal transducing proteins, including Src family members, Grb2, and the p85 subunit of PI3 kinase, which mediate ErbB downstream signaling. Both Tyr1222 and Tyr1289 of ErbB3 reside within a YXXM motif and participate in signaling to PI3K.
- Shipping Conditions:
- Blue Ice