AN301798L
Recombinant PTP1B Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301798L
- Additional Names:
- PTPN,PTPN1,PTP1B
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human PTP1B fragment
- Clone:
- A510
- Uniprot:
- P18031
- Synonyms:
- protein tyrosine phosphatase, placental;protein-tyrosine phosphatase 1B;PTP1B;tyrosine-protein phosphatase non-receptor type 1
- Extra Details:
- PTP1B is the founding member of the protein tyrosine phosphatase (PTP) family and PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation.
- Shipping Conditions:
- Blue Ice