AN301767L
Recombinant Topoisomerase I Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301767L
- Additional Names:
- TOP,TOP1,TOPI
- Application:
- Flow Cytometry, IHC, WB, IF, IP
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human Topoisomerase I fragment
- Clone:
- A475
- Uniprot:
- P11387
- Synonyms:
- DNA topoisomerase 1;DNA topoisomerase I;Scl-70 antigen;TOPI;topoisomerase (DNA) I;type I DNA topoisomerase
- Extra Details:
- DNA topoisomerases play essential roles in many DNA metabolic processes including DNA repair. Topoisomerases can introduce DNA damage upon exposure to drugs that stabilize the covalent protein-DNA intermediate of the topoisomerase reaction. Lesions in DNA are also able to trap topoisomerase-DNA intermediates. DNA topoisomerase I (Top1) catalyzes the relaxation of supercoiled DNA by a mechanism of transient DNA strand cleavage characterized by the formation of a phosphotyrosyl bond between the DNA end and active site tyrosine.
- Shipping Conditions:
- Blue Ice