AN301679L
Recombinant TPX2 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301679L
- Additional Names:
- FLS,HCA,TPX,HCTP,REPP,GD:C20orf,DIL,DIL2,p100,DIL-2,HCTP4,FLS353,HCA519,REPP86,C20orf1,C20orf2,GD:C20orf1,TPX2,Chromosome 20 Open Reading Frame 1,Differentially expressed in cancerous and noncancerous lung cells 2,Differentially expressed in cancerous and non-cancerous lung cells 2,Differentially expressed in lung cells,Differentially expressed in lung cells 2,DIL 2,HCA 519,HCTP 4,Hepatocellular carcinoma associated antigen 519,Hepatocellular carcinoma-associated antigen 519,Preferentially
- Application:
- Flow Cytometry, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human TPX2 fragment
- Clone:
- A382
- Uniprot:
- Q9ULW0
- Synonyms:
- C20orf1;C20orf2;differentially expressed in cancerous and non-cancerous lung cells 2;differentially expressed in lung cells;DIL-2;DIL2;FLS353;GD:C20orf1;HCA519;HCTP4;hepatocellular carcinoma-associated antigen 519;hepatocellular carcinoma-associated antigen 90;p100;preferentially expressed in colorectal cancer;protein fls353;REPP86;restricted expression proliferation associated protein 100;Restricted expression proliferation-associated protein 100;targeting protein for Xklp2;TPX2, microtubule-associated protein homolog;TPX2, microtubule-associated, homolog
- Extra Details:
- Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules.Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha .At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.
- Shipping Conditions:
- Blue Ice