AN301652L
Recombinant SATB1 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301652L
- Additional Names:
- SATB,SATB1
- Application:
- Flow Cytometry, IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human SATB1 fragment
- Clone:
- A355
- Uniprot:
- Q01826
- Synonyms:
- DEFDA;DNA-binding protein SATB1;KTZSL;special AT-rich sequence binding protein 1 (binds to nuclear matrix/scaffold-associating DNA);Special AT-rich sequence-binding protein 1
- Extra Details:
- Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g., PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation.
- Shipping Conditions:
- Blue Ice