Recombinant PKN1 Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301632L
Additional Names:: PRK,PRKCL,PAK,PKN1,DBK,PAK-1,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1,Protein kinase N1
Application:: WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human PKN1 fragment
Clone:: A335
Uniprot:: Q16512
Synonyms:: DBK;PAK-1;PAK1;PKN;PKN-ALPHA;PRK1;PRKCL1;protease-activated kinase 1;protein kinase C-like 1;protein kinase C-like PKN;protein kinase C-related kinase 1;protein kinase PKN-alpha;Protein-kinase C-related kinase 1;serine-threonine kinase N;Serine-threonine protein kinase N;serine/threonine protein kinase N;serine/threonine-protein kinase N1
Extra Details:: PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus.

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