AN301629L
Recombinant PI3 Kinase p85 alpha Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301629L
- Additional Names:
- GRB,IMD,AGM,PIK3R,AGM7,GRB1,IMD36,p85,p85-ALPHA,PI3 Kinase p85 alpha,PIK3R1,p85 alpha,P85A,Phosphatidylinositol 3 kinase,Phosphatidylinositol 3 kinase associated p 85 alpha,Phosphatidylinositol 3 kinase regulatory 1,Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha,Phosphatidylinositol 3-kinase regulatory subunit alpha,Phosphoinositide 3 kinase,PI3 kinase p85 subunit alpha,PI3K,PI3K regulatory subunit alpha,PI3-kinase regulatory subunit alpha,PI3-kinase subunit
- Application:
- IHC, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human PI3 Kinase p85 alpha fragment
- Clone:
- A332
- Uniprot:
- P27986
- Synonyms:
- AGM7;GRB1;IMD36;p85;p85-ALPHA;phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha;phosphatidylinositol 3-kinase regulatory subunit alpha;phosphatidylinositol 3-kinase-associated p-85 alpha;phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha);phosphoinositide-3-kinase regulatory subunit alpha;phosphoinositide-3-kinase, regulatory subunit 1 (alpha);PI3-kinase subunit p85-alpha;PI3K regulatory subunit alpha;ptdIns-3-kinase regulatory subunit alpha
- Extra Details:
- Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling. Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement.
- Shipping Conditions:
- Blue Ice