AN301627L
Recombinant PHB2 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301627L
- Additional Names:
- PHB,BCAP,PNAS,PHB2,BAP,BCAP37,Bap37,PNAS-141,REA,hBAP,p22
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human PHB2 fragment
- Clone:
- A330
- Uniprot:
- Q99623
- Synonyms:
- B cell receptor associated protein 37;B-cell associated protein;B-cell receptor-associated protein BAP37;BAP;Bap37;BCAP37;D-prohibitin;hBAP;p22;PNAS-141;prohibitin-2;REA;repressor of estrogen receptor activity
- Extra Details:
- Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus.In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation.
- Shipping Conditions:
- Blue Ice