Recombinant eIF3B Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301513L
Additional Names:: PRT,EIF3S,EIF3B,EIF3-ETA,EIF3-P110,EIF3-P116,EIF3S9,PRT1
Application:: IHC, WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human eIF3B1 fragment
Clone:: A212
Uniprot:: P55884
Synonyms:: eIF-3-eta;eIF3 p110;eIF3 p116;EIF3-ETA;EIF3-P110;EIF3-P116;EIF3S9;eukaryotic translation initiation factor 3 subunit 9;eukaryotic translation initiation factor 3 subunit B;eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD);eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa;protein synthesis 1;PRT1;prt1 homolog
Extra Details:: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2: GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. UniRule annotation4 Publications (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.

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