Recombinant CD79a Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301486L
Additional Names:: CD79A,IGA,MB-1,CD79a molecule,CD79A antigen,MB1,MB1,Ig&amp,alpha
Application:: IHC, WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human CD79a fragment
Clone:: A181
Uniprot:: P11912
Synonyms:: B-cell antigen receptor complex-associated protein alpha chain;CD79a antigen (immunoglobulin-associated alpha);CD79a molecule, immunoglobulin-associated alpha;ig-alpha;IGA;MB-1;MB-1 membrane glycoprotein;membrane-bound immunoglobulin-associated protein;surface IgM-associated protein
Extra Details:: Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells.