AN301472L
Recombinant CD25 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301472L
- Additional Names:
- IMD,IDDM,IL2RA,CD25,IDDM10,IL2R,IMD41,TCGFR,p55,IL-2 receptor subunit alpha,IL-2R subunit alpha,IL2-RA,IL-2-RA,IL-2RA Alpha,Interleukin-2 receptor subunit alpha,TAC antigen,Tac,p55,IL-2R&,alpha,alpha chain,CD25 antigen,IL 2 receptor alpha subunit,IL2 RA,Interleukin 2 receptor,Interleukin 2 receptor alpha,Interleukin 2 receptor alpha chain,t-cell growth factor receptor
- Application:
- Flow Cytometry, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human CD25 fragment
- Clone:
- A167
- Uniprot:
- P01589
- Synonyms:
- CD25;IDDM10;IL-2 receptor subunit alpha;IL-2R subunit alpha;IL2R;IMD41;interleukin 2 receptor, alpha;interleukin-2 receptor subunit alpha;p55;TAC antigen;TCGFR
- Extra Details:
- The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.
- Shipping Conditions:
- Blue Ice