AN301428L
Recombinant AKT1 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301428L
- Additional Names:
- CWS,MGC,AKT serine/threonine kinase,AKT,CWS6,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA,AKT1,AKT 1,AKT serine/threonine kinase 1,AKT1_HUMAN,MGC99656,Protein kinase B,Protein Kinase B Alpha,Proto-oncogene c-Akt,RAC Alpha,RAC-alpha serine/threonine-protein kinase,RAC-PK-alpha,AKT,AKT serine/threonine kinase 1,CWS6,PKB,PKB-ALPHA,PRKBA,RAC,RAC-ALPHA
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human AKT1 fragment
- Clone:
- A123
- Uniprot:
- P31749
- Synonyms:
- AKT;AKT1m;PKB;PKB alpha;PKB-ALPHA;PRKBA;Protein kinase B;protein kinase B alpha;proto-oncogene c-Akt;RAC;rac protein kinase alpha;RAC-ALPHA;RAC-alpha serine/threonine-protein kinase;RAC-PK-alpha;serine-threonine protein kinase;v-akt murine thymoma viral oncogene homolog 1;v-akt murine thymoma viral oncogene-like protein 1
- Extra Details:
- The serine-threonine protein kinase AKT1 is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.
- Shipping Conditions:
- Blue Ice