AN301427L
Recombinant Activin A Receptor Type IB/ALK-4 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301427L
- Additional Names:
- SKR,Activin Receptor-Like Kinase,Serine/Threonine-Protein Kinase Receptor R,ACVRLK,ALK,ACVR1B,ACTRIB,ACVRLK4,ALK4,SKR2,Activin Receptor Type IB,Activin Receptor Type-1B,Activin Receptor-Like Kinase 4,ACTR-IB,ALK-4,Serine/Threonine-Protein Kinase Receptor R2
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human Activin A Receptor Type IB/ALK-4 fragment
- Clone:
- A122
- Uniprot:
- P36896
- Synonyms:
- activin A receptor, type IB;activin A receptor, type II-like kinase 4;Activin receptor type IB;activin receptor type-1B;activin receptor-like kinase 4;ACTRIB;ACVRLK4;ALK4;serine/threonine-protein kinase receptor R2;SKR2
- Extra Details:
- Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail.
- Shipping Conditions:
- Blue Ice