Recombinant SREBP-1 Monoclonal Antibody

Size

£311.40

Was £346.00

SKU:: AN301398L
Additional Names:: BHLHD,SREBP,SREBF,BHLHD1,SREBP1,SREBF1
Application:: IHC
Concentration:: 0.2 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant Human SREBP-1 protein
Clone:: B1165
Uniprot:: P36956
Synonyms:: bHLHd1;class D basic helix-loop-helix protein 1;HMD;IFAP2;SREBP1;sterol regulatory element-binding protein 1;Sterol regulatory element-binding transcription factor 1
Extra Details:: This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17.