AN301387L
Recombinant Rb Monoclonal Antibody
Size
£311.40
Was £346.00
- SKU:
- AN301387L
- Additional Names:
- PPP1R,OSRC,PPP1R130,RB,p105-Rb,pRb,pp110,RB1,Exon 17 tumor GOS561 substitution mutation causes premature stop,GOS563 exon 17 substitution mutation causes premature stop,Osteosarcoma,P105RB,PP105,Prepro retinoblastoma associated protein,Protein phosphatase 1 regulatory subunit 130,RB transcriptional corepressor 1,RB1 gene,retinoblastoma 1,Retinoblastoma protein,Retinoblastoma suspectibility protein,Retinoblastoma-associated protein
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human Rb protein
- Clone:
- B1154
- Uniprot:
- P06400
- Synonyms:
- exon 17 tumor GOS561 substitution mutation causes premature stop;GOS563 exon 17 substitution mutation causes premature stop;OSRC;p105-Rb;p110-RB1;pp110;PPP1R130;pRb;prepro-retinoblastoma-associated protein;protein phosphatase 1, regulatory subunit 130;RB;retinoblastoma 1;retinoblastoma suspectibility protein;retinoblastoma-associated protein
- Extra Details:
- The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
- Shipping Conditions:
- Blue Ice