AN301369L
Recombinant 53BP1 Monoclonal Antibody
Size
£311.40
Was £346.00
- SKU:
- AN301369L
- Additional Names:
- 53BP,TDRD,tumor protein p53 binding protein,p53BP,TP53BP,TP53BP1,53BP1,TDRD30,TP53,p202,p53BP1,tumor protein p53 binding protein 1,53BP1,p202,p53BP1,TDRD30,TP53,tumor protein p53 binding protein 1
- Application:
- IHC, WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human 53BP1 protein
- Clone:
- B1136
- Uniprot:
- Q12888
- Synonyms:
- 53BP1;p202;p53-binding protein 1;p53BP1;TDRD30;TP53-binding protein 1;tumor protein 53-binding protein, 1;tumor suppressor p53-binding protein 1
- Extra Details:
- This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Shipping Conditions:
- Blue Ice