AN301341L
Recombinant Calponin-1 Monoclonal Antibody
Size
£311.40
Was £346.00
- SKU:
- AN301341L
- Additional Names:
- CNN,Calponin H,HEL-S,Calponin,CNN1,HEL-S-14,SMCC,Sm-Calp,Calponin H1,Calponin-1,smooth muscle,CNN1,HEL-S-14,SMCC,Sm-Calp
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human Calponin-1 protein
- Clone:
- B1108
- Uniprot:
- P51911
- Synonyms:
- basic calponin;calponin 1, basic, smooth muscle;calponin H1, smooth muscle;calponin-1;calponins, basic;epididymis secretory protein Li 14;HEL-S-14;Sm-Calp;SMCC
- Extra Details:
- CNN-1 (Calponin 1 [calcium and calmodulin-binding troponin T-like protein], also Calponin basic, CaP and Calponin H1) is a 32-36 kDa cytoplasmic member of the calponin family of proteins. Although reportedly expressed in fibroblasts and endothelial cells, it actually appears to be restricted to smooth muscle and smooth muscle-like cells such as myoepithelium and myofibroblasts in the adult. CNN-1 interacts with F-actin in a phosphorylation-dependent manner. When nonphosphorylated, CNN-1 blocks actomyosin ATPase activity, contributing to the stabilization of actin stress fiber bundles. Thus, CNN-1 expression inhibits cell motility and the formation of podosomes. Human CNN-1 is 297 amino acids (aa) in length. It contains one CH/calponin homology domain (aa 30-127), and three consecutive calponin-like repeats (aa 164-268). The repeats are suggested to mediate actin binding. There are five potential Ser/Thr phosphorylation sites. Full-length human CNN-1 shares 97% aa sequence identity with mouse CNN-1.
- Shipping Conditions:
- Blue Ice