AN301184L
Recombinant FRS2 Monoclonal Antibody
Size
£221.40
Was £246.00
- SKU:
- AN301184L
- Additional Names:
- FRS,FRS2,FRS1A,FRS2A,FRS2alpha,SNT,SNT-1,SNT1,fibroblast growth factor receptor substrate 2,FRS2
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human FRS2 protein
- Clone:
- B943
- Uniprot:
- Q8WU20
- Synonyms:
- epididymis secretory sperm binding protein;FGFR signalling adaptor;FGFR substrate 2;FGFR-signaling adaptor SNT;fibroblast growth factor receptor substrate 2;FRS1A;FRS2A;FRS2alpha;SNT;SNT-1;SNT1;suc1-associated neurotrophic factor target 1
- Extra Details:
- Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.,PTM:Phosphorylated on tyrosine residues upon stimulation by NGF.,PTM:Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.,sequence caution:Translated as stop.,similarity:Contains 1 IRS-type PTB domain.,subcellular location:Cytoplasmic, membrane-bound.,subunit:Part of a complex containing FRS2, GRB2 and SOS1. Part of a complex containing GRB2 and CBL. Binds RET (By similarity). Binds FGFR1, SUC1, NTRK1, NTRK2, NTRK3 and SRC. The tyrosine-phosphorylated protein binds the SH2 domains of GRB2 and PTPN11.,tissue specificity:Highly expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis.
- Shipping Conditions:
- Blue Ice