Recombinant Calreticulin Monoclonal Antibody

Size

£221.40

Was £246.00

SKU:: AN301032L
Additional Names:: CRP,ERp,endoplasmic reticulum resident protein,CaBP,CALR,CRT,HEL-S-99n,RO,SSA,cC1qR,CaBP3,calregulin,Calreticulin,calsequestrin-like protein,CRP55,endoplasmic reticulum resident protein 60,ERp60,CRTC,Autoantigen RO,CALR protein,calreticulin),Epididymis secretory sperm binding protein Li 99n,FLJ26680,grp60,HACBP,HEL S 99n,Sicca syndrome antigen A,Sicca syndrome antigen A (autoantigen Ro,Calregulin
Application:: IHC, WB
Concentration:: 0.2 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant Human Calreticulin protein
Clone:: B783
Uniprot:: P27797
Synonyms:: calregulin;calreticulin;cC1qR;CRP55;CRT;endoplasmic reticulum resident protein 60;epididymis secretory sperm binding protein Li 99n;ERp60;grp60;HACBP;HEL-S-99n;RO;Sicca syndrome antigen A (autoantigen Ro; calreticulin);SSA
Extra Details:: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.

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