AN301016L
Recombinant Phospho-MSK1 (Ser360) Monoclonal Antibody
Size
£221.40
Was £246.00
- SKU:
- AN301016L
- Additional Names:
- MSK,MSPK,RPS6KA,RPS6KA5,MSK1,MSPK1,RLPK,90 kDa ribosomal protein S6 kinase 5,EC 2.7.11.1,KS6A5,MGC1911,Mitogen and stress activated protein kinase 1,Nuclear Mitogen And Stress Activated Protein Kinase 1,Nuclear mitogen- and stress-activated protein kinase 1,Ribosomal protein S6 kinase 90kD polypeptide 5,Ribosomal protein S6 kinase 90kDa,Ribosomal protein S6 kinase 90kDa polypeptide 5,Ribosomal Protein S6 Kinase Alpha 5,Ribosomal protein S6 kinase alpha-5,RSK Like Protein Kinase,RSKL,RSK-like
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- A synthetic peptide corresponding to residues around (Ser360) of Human Phospho-MSK1
- Clone:
- B767
- Uniprot:
- O75582
- Synonyms:
- 90 kDa ribosomal protein S6 kinase 5;MSK1;MSPK1;nuclear mitogen- and stress-activated protein kinase 1;ribosomal protein S6 kinase alpha-5;ribosomal protein S6 kinase, 90kDa, polypeptide 5;RLPK;RSK-like protein kinase;RSKL;S6K-alpha-5
- Extra Details:
- ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,enzyme regulation:Appears to be activated by multiple phosphorylations on threonine and serine residues. ERK1/2 and MAPK14/p38-alpha may play a role in this process.,Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).,miscellaneous:Enzyme activity requires the presence of both kinase domains.,PTM:Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subcellular location:Predominantly nuclear. Partially cytoplasmic.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells which transiently dissociates following mitogenic stimulation. Also associates with MAPK14/p38-alpha. Activated RPS6KA5 associates with and phosphorylates the NF-kappa-B p65 subunit RELA.,tissue specificity:Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
- Shipping Conditions:
- Blue Ice