AN300840L
Recombinant p21 Monoclonal Antibody
Size
£221.40
Was £246.00
- SKU:
- AN300840L
- Additional Names:
- Cip,Waf,Cip1,Waf1,Cdkn1a,CAP20,CDKN1,cyclin dependent kinase inhibitor 1A,cyclin-dependent kinase inhibitor 1A,MDA-6,P21,PIC1,SDI1
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Mouse p21 protein
- Clone:
- B783
- Uniprot:
- P39689
- Synonyms:
- CAP;CAP20;CDK;CDK-interacting protein 1;CDKI;Cdkn;Cdkn1;CI;CIP1;cyclin-dependent kinase inhibitor 1;mda;mda6;melanoma differentiation-associated protein;P2;P21;p21C;p21Cip1;p21W;p21WAF;SD;SDI1;Waf;Waf1
- Extra Details:
- This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation.
- Shipping Conditions:
- Blue Ice