AN300827L
Recombinant Smad4 Monoclonal Antibody
Size
£221.40
Was £246.00
- SKU:
- AN300827L
- Additional Names:
- DPC,MADH,MAD Homolog,SMAD family member,Mothers Against DPP Homolog,Deletion Target in Pancreatic Carcinoma,Mothers Against Decapentaplegic Homolog,hSMAD,SMAD4,DPC4,JIP,MADH4,MYHRS,SMAD family member 4,Deletion Target in Pancreatic Carcinoma 4,hSMAD4,MAD Homolog 4,Mothers Against Decapentaplegic Homolog 4,Mothers Against DPP Homolog 4,SMAD 4,DPC4,JIP,MADH4,MYHRS,SMAD family member 4,(Small) Mothers Against Decapentaplegic,Deleted in Pancreatic Carcinoma,Deleted in Pancreatic Carcinoma
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human Smad4 protein
- Clone:
- B770
- Uniprot:
- Q13485
- Synonyms:
- deleted in pancreatic carcinoma locus 4;deletion target in pancreatic carcinoma 4;DPC4;JIP;MAD homolog 4;MADH4;mothers against decapentaplegic homolog 4;mothers against decapentaplegic, Drosophila, homolog of, 4;MYHRS;SMAD family member 4;SMAD, mothers against DPP homolog 4
- Extra Details:
- This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
- Shipping Conditions:
- Blue Ice