AN300716L
Recombinant MLKL Monoclonal Antibody
Size
£221.40
Was £246.00
- SKU:
- AN300716L
- Additional Names:
- hMLKL,MLKL,9130019I15Rik,FLJ34389,Mixed lineage kinase domain like,Mixed lineage kinase domain like protein,Mixed lineage kinase domain like pseudokinase,Mixed lineage kinase domain-like protein
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human MLKL protein
- Clone:
- B655
- Uniprot:
- Q8NB16
- Synonyms:
- hMLKL;mixed lineage kinase domain-like protein
- Extra Details:
- This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
- Shipping Conditions:
- Blue Ice