AN300709L
Recombinant CTCF Monoclonal Antibody
Size
£221.40
Was £246.00
- SKU:
- AN300709L
- Additional Names:
- MRD,Cancer/testis antigen,CTCF,MRD21,11-Zinc Finger Protein,BORIS,Brother of the regulator of imprinted sites,Cancer/testis antigen 27,CCCTC-Binding Factor,CT27,CTCF paralog,CTCFL,CTCFL Paralog,CTCF-like protein,Transcriptional Repressor CTCF,Transcriptional repressor CTCFL,Zinc finger protein CTCF-T
- Application:
- WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant Human CTCF protein
- Clone:
- B648
- Uniprot:
- P49711
- Synonyms:
- 11 zinc finger transcriptional repressor;11-zinc finger protein;CCCTC-binding factor;CCCTC-binding factor (zinc finger protein);CFAP108;CTCFL paralog;FAP108;MRD21;transcriptional repressor CTCF
- Extra Details:
- This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms&apos, tumors.
- Shipping Conditions:
- Blue Ice