Recombinant XIAP Monoclonal Antibody

Size

£221.40

Was £246.00

SKU:: AN300702L
Additional Names:: ILP,XLP,API,BIRC,Inhibitor of apoptosis protein,Baculoviral IAP repeat-containing protein,IAP,XIAP,API3,BIRC4,IAP-3,ILP1,MIHA,XLP2,hIAP-3,hIAP3,X-linked inhibitor of apoptosis,Baculoviral IAP repeat-containing protein 4,E3 ubiquitin-protein ligase XIAP,IAP-like protein,Inhibitor of apoptosis protein 3,RING-type E3 ubiquitin transferase XIAP,X-linked inhibitor of apoptosis protein,IAP3
Application:: WB
Concentration:: 0.2 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant Human XIAP protein
Clone:: B641
Uniprot:: P98170
Synonyms:: API3;baculoviral IAP repeat-containing protein 4;BIRC4;E3 ubiquitin-protein ligase XIAP;hIAP-3;hIAP3;IAP-3;IAP-like protein;IAP-like protein 1;ILP1;inhibitor of apoptosis protein 3;MIHA;RING-type E3 ubiquitin transferase XIAP;X-linked IAP;X-linked inhibitor of apoptosis protein;X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase;XLP2
Extra Details:: This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.

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