Recombinant PDPK1 Monoclonal Antibody

Size

£221.40

Was £246.00

SKU:: AN300667L
Additional Names:: PDK,PRO,3-phosphoinositide-dependent protein kinase,PDPK1,PDK1,PDPK2,PDPK2P,PRO0461,3-phosphoinositide-dependent protein kinase 1,3-phosphoinositide-dependent protein kinase 1,PDK1,PDPK2,PDPK2P,PRO0461,3 phosphoinositide dependent protein kinase 1,hPDK 1,hPDK1,MGC20087,MGC35290,OTTHUMP00000159109,OTTHUMP00000159110,OTTHUMP00000174525,PkB kinase,PkB kinase like gene 1,PkB like 1,Protein kinase
Application:: WB
Concentration:: 0.2 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant Human PDPK1 protein
Clone:: B606
Uniprot:: O15530
Synonyms:: 3-phosphoinositide-dependent protein kinase 1;3-phosphoinositide-dependent protein kinase 2 pseudogene;PDK1;PDPK2;PDPK2P;PkB kinase like gene 1;PRO0461
Extra Details:: ATP + a protein = ADP + a phosphoprotein.,Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive.,PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane.,subunit:Interacts with TUSC4.,tissue specificity:Appears to be expressed ubiquitously.

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