Recombinant ZAP-70 Monoclonal Antibody

Size

£221.40

Was £246.00

SKU:: AN300642L
Additional Names:: IMD,ADMIO,ZAP,ZAP70,ADMIO2,IMD48,SRK,STCD,STD,TZK,ZAP-70,70 kDa zeta associated protein,70 kDa zeta-associated protein,EC 2.7.10.2,FLJ17670,FLJ17679,Selective T cell defect,Syk related tyrosine kinase,Syk-related tyrosine kinase,Truncated ZAP kinase,Tyrosine protein kinase ZAP70,Tyrosine-protein kinase ZAP-70,ZAP 70,Zeta chain associated protein kinase 70kD,Zeta chain associated protein kinase 70kDa,Zeta chain associated protein kinase 70kDa isoform 1,Zeta chain associated protein kinase 70kDa
Application:: WB
Concentration:: 0.2 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant Human ZAP-70 protein
Clone:: B577
Uniprot:: P43403
Synonyms:: 70 kDa zeta-associated protein;70 kDa zeta-chain associated protein;ADMIO2;IMD48;SRK;STCD;STD;syk-related tyrosine kinase;tyrosine-protein kinase ZAP-70;TZK;ZAP-70;zeta chain of T cell receptor associated protein kinase 70kDa;zeta-chain (TCR) associated protein kinase 70kDa;zeta-chain associated protein kinase, 70kD
Extra Details:: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.

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