Recombinant CD166/ALCAM Monoclonal Antibody

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£361.80

Was £402.00

SKU:: AN300586P
Additional Names:: UCHL,Uchl1,HEL-117,HEL-S-53,NDGOA,PARK5,PGP 9.5,PGP9.5,PGP95,SPG79,Ubiquitin C-terminal hydrolase L1,Uch-L1
Application:: WB, IP
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Rat
Buffer:: PBS
Immunogen:: Recombinant Rat CD166/ALCAM protein
Clone:: B521
Uniprot:: Q00981
Synonyms:: neuron cytoplasmic protein 9.5;PGP 9.5;PGP9.5;ubiquitin carboxy-terminal hydrolase L1;ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase);ubiquitin carboxyl-terminal hydrolase isozyme L1;ubiquitin thioesterase L1;UCH-L1
Extra Details:: Activated leukocyte cell adhesion molecule (ALCAM)/Cluster of differentiation (CD166) is a type I transmembrane cell adhesion molecule belonging to the Ig superfamily and a ligand for CD6 that is expressed on T lymphocytes. The extracellular domain of ALCAM contains five Ig-like domains (three Ig-like C2-type domains and two Ig-like V-type domains), of which the amino-terminal V1 domain is essential for ligand binding and ALCAM-mediated cell aggregation. ALCAM mediates both heterophilic (ALCAM-CD6) and homophilic (ALCAM-ALCAM) cell-cell interactions. ALCAM/CD6 interaction plays a role in T cell development and T cell regulation, as well as in the binding of T- and B-cells to activated leukocytes. Recently, homophilic (ALCAM-ALCAM) adhesion was shown to play important roles in tight cell-to-cell interaction and regulation of stem cell differentiation. While expressed in a wide variety of tissues, ALCAM is usually restricted to subsets of cells involved in dynamic growth and/or migration, including neural development, branching organ development, hematopoiesis, immune response and tumor progression. And CD166 is regarded as a potential novel breast cancer indicator and therapeutic target.

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