AN300501P
Recombinant PPM1A/PP2CA Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300501P
- Additional Names:
- Pppm1a,Ppm1a,2310003C21Rik,2900017D14Rik,AI427932,AU017636,MMPa-2,MPPa-1
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse PPM1A/PP2CA Protein
- Clone:
- B431
- Uniprot:
- P49443
- Synonyms:
- 2310003C21Rik;2900017D14Rik;AI427932;AU017636;MMPa;MMPa-2;MPP;Mpp alpha;MPPa-1;PP2C-alpha;protein phosphatase 1A;Protein phosphatase 2C isoform alpha;protein phosphatase IA
- Extra Details:
- Protein phosphatase 1A (PPM1A/PP2CA) is an enzyme belonging to the PP2C family of Ser/Thr protein phosphatases. Members of PP2C family are negative regulators of cell stress response pathways and the MAP kinases and MAP kinase kinases. It has also been demonstrated to inhibit the activation of p38 and JNK kinase cascades. PPM1A dephosphorylates and promotes nuclear export of TGFB Beta-activated Smad2/3. Ectopic expression of PPM1A abolishes TGFB Beta-induced antiproliferative and transcriptional responses, whereas depletion of PPM1A enhances TGFB Beta signaling in mammalian cells. It has been demonstrated that PPM1A/PP2CA, through dephosphorylation of Smad2/3, plays a critical role in terminating TGFB Beta signaling. Overexpression of PPM1A is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to cell apoptosis.
- Shipping Conditions:
- Blue Ice