AN300482P
Recombinant CD4 Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300482P
- Additional Names:
- L3T,T-cell surface antigen T4/Leu,T-cell surface glycoprotein CD,L3T4,Ly-4,T4,T-cell surface antigen T4/Leu-3,T-cell surface glycoprotein CD4,Cd4,L3T4,CD4mut,p55
- Application:
- Flow Cytometry, IF, ICC
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse CD4 Protein
- Clone:
- B412
- Uniprot:
- P06332
- Synonyms:
- L3T;L3T4;Ly-;Ly-4;T-cell differentiation antigen L3T4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Shipping Conditions:
- Blue Ice