AN300478P
Recombinant SerpinD1/HCII Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300478P
- Additional Names:
- Hcf,Heparin cofactor,Protease inhibitor leuserpin,SERPIND,Serpin D,HC-II,Heparin cofactor 2,Heparin cofactor II,Protease inhibitor leuserpin-2,Serpin D1,Hcf2,Hcii,Serpind1,HC II,HC2,HLS2,LS2,Serpin Peptidase Inhibitor Clade D Member 1,THPH10
- Application:
- WB, IP
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse SerpinD1 protein
- Clone:
- B408
- Uniprot:
- P49182
- Synonyms:
- AA985900;AI303446;HC;HC-II;Hcf2;HCII;heparin cofactor 2;heparin cofactor II;protease inhibitor leuserpin-2;serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1;serpin D1
- Extra Details:
- SerpinD1, also known as heparin cofactor II, is a member of Serpin superfamily of the serine proteinase inhibitors. HCII is a glycoprotein in human plasma that inhibits thrombin and chymotrypsin, and the rate of inhibition of thrombin is rapidly increased by Dermatan sulfate (DS), heparin (H) and glycosaminoglycans(GAG). The stimulatory effect of glycosaminoglycans on the inhibition is mediated, in part, by the N-terminal acidic domain of HCII. Interestingly, a C-terminal His-tagged recombinant HCII exhibits enhanced activity of thrombin inhibition. It has been suggested that HCII plays an unique and important role in vascular homeostasis, and accordingly mutations in this gene or congenital HCII deficiency is potentially associated with thrombosis. HCII specifically inhibits thrombin action at the site of vascular wall injury and HCII-thrombin complexes have been detected in human plasma. HCII protects against thrombin-induced vascular remodeling in both humans and mice and HCII is a predictive biomarker and therapeutic target for atherosclerosis. SerpinD1 also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner.
- Shipping Conditions:
- Blue Ice