AN300473P
Recombinant CD132/IL2RG Monoclonal Antibody
Size
£170.10
Was £189.00
- SKU:
- AN300473P
- Additional Names:
- CD132,Cytokine receptor common subunit gamma,gammaC,IL-2 receptor subunit gamma,IL-2R subunit gamma,IL-2RG,Interleukin-2 receptor subunit gamma,p64,Il2rg,common &,gamma- chain-n,IL-2R&,gamma,gamma(c)
- Application:
- Flow Cytometry, IF, ICC
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- PBS
- Immunogen:
- Recombinant Mouse CD132/IL2RG Protein
- Clone:
- B403
- Uniprot:
- P34902
- Synonyms:
- [g]c;CD132;common gamma chain;cytokine receptor common subunit gamma;gamm;gamma C receptor;gamma(;gamma(c);gammaC;gc;IL-2 receptor subunit gamma;IL-2R subunit gamma;interleukin-2 receptor subunit gamma;p64
- Extra Details:
- The common gamma chain (G Gammac) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (G Gammac) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.
- Shipping Conditions:
- Blue Ice