Recombinant CXADR Monoclonal Antibody

Size

£361.80

Was £402.00

SKU:: AN300458P
Additional Names:: Coxsackievirus and adenovirus receptor homolog,CVB3 BP,MCVADR,Car,Cxadr
Application:: IHC-P
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: Recombinant Mouse CXADR protein
Clone:: B384
Uniprot:: P97792
Synonyms:: 2610206D03Rik;AU016810;AW553441;C;CAR;coxsackievirus and adenovirus receptor homolog;MC;MCAR;MCV;MCVADR
Extra Details:: CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 17 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 9% sequence identity with the corresponding regions of rat, human CXADR.