AN300387P
Recombinant NAALADL1/NAALADase L Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300387P
- Additional Names:
- NAALADASEL,NAALADL,NAALADL1,I100
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human NAALADL1 protein
- Clone:
- B313
- Uniprot:
- Q9UQQ1
- Synonyms:
- 100 kDa ileum brush border membrane protein;aminopeptidase NAALADL1;HILAP;human ileal aminopeptidase;I100;ileal dipeptidylpeptidase;ileal peptidase I100;N-acetylated-alpha-linked acidic dipeptidase-like protein;NAALADase L;NAALADASEL;peptidase homolog
- Extra Details:
- N-acetylated-alpha-linked acidic dipeptidase-like protein, also known as NAALADL1, NAALADase L, and Ileal dipeptidyl-peptidase, is a Single-pass type II membrane protein and a member of the peptidase M28 family and M28B subfamily. NAALADase L is mainly expressed in the distal small intestine. It is also expressed in the spleen and testis and Weakly expressed in the brain, locating mainly to the brain stem, amygdala, thalamus, and ventral striatum. NAALADase L is a chloride-activated, membrane-bound, metallopeptidase that cleaves the endogenous neuropeptide N-acetyl-aspartyl-glutamate (NAAG). NAAG acts as a partial NMDA agonist as well as a full agonist at the presynaptic metabotropic glutamate receptor 3 (mGluR3), where it acts to reduce glutamate release. NAALADase L also exhibits a dipeptidyl-peptidase IV type activity. NAALADase inhibition may be a novel therapeutic approach to reduce or inhibit heightened aggressiveness, and possibly to treat aggressive behavior associated with psychiatric disorders.
- Shipping Conditions:
- Blue Ice