AN300305P
Recombinant IL18RAP/IL1R7 Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300305P
- Additional Names:
- IL1R,ACPL,CD218b,CDw218b,IL-18RAcP,IL18RB,IL-18Rbeta,IL-18R-beta,IL-1R7,IL-1R-7,IL-1RAcPL,IL1R7,IL18RAP,IL-1RcPL,CDw218b,IL18R&,beta,Accessory protein like,Accessory protein-like,CD218 antigen-like family member B,I18RA,IL 18RAcP,IL 1R accessory protein like,IL 1R7,IL 1RAcPL,IL-18 receptor accessory protein,IL18Rbeta,IL-1R accessory protein-like,Interleukin 18 receptor accessory protein,Interleukin-1 receptor 7,Interleukin-18 receptor accessory protein,Interleukin-18 receptor accessory
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human IL18RAP/IL1R7 Protein
- Clone:
- B227
- Uniprot:
- O95256
- Synonyms:
- Accessory protein-like;ACPL;CD218 antigen-like family member B;CD218b;CDw218b;cluster of differentiation w218b;IL-18 receptor accessory protein;IL-18 receptor beta;IL-18R-beta;IL-18RAcP;IL-18Rbeta;IL-1R accessory protein-like;IL-1R-7;IL-1R7;IL-1RAcPL;IL18RB;interleukin-1 receptor 7;interleukin-18 receptor accessory protein;Interleukin-18 receptor accessory protein-like;interleukin-18 receptor beta
- Extra Details:
- Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (cluster of differentiation w218b), is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of IL18R1 (IL1RRP), a ligand-binding subunit of the IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of NF-kappaB and MAPK8 (JNK) in response to IL18. IL18RAP is required for the high-affinity binding of interleukin 18 (IL-18) to its receptor complex. IL18RAP together with IL18R1 mediates IL-18-dependent activation of NF-kappa-B and JNK. Two putative isoforms of IL18RAP were detected and the ratios and total levels of these isoforms may contribute to the etiology of coeliac disease. IL18R1 and IL18RAP polymorphisms have been found associated with diseases such as schizophrenia, HSV1 seropositivity, and atopic asthma. Analysis of IL18R1 and IL18RAP SNPs in 5 European prospective cohorts suggests that the variability of these genes are unlikely to contribute to modulate the risk of CVD in European populations.
- Shipping Conditions:
- Blue Ice