AN300185P
Recombinant VE-Cadherin/CD144 Monoclonal Antibody
Size
£170.10
Was £189.00
- SKU:
- AN300185P
- Additional Names:
- CDH,Cadherin 5 Type,cadherin,CDH5,7B4,CD144,cadherin-5,Cadherin 5 Type 2,VE-Cadherin,Cadherin-5,7B 4,7B4 antigen,CADH5,Cadherin 5,Cadherin5,CD 144,CD144 antigen,CDH 5,CDH5 protein,Endothelial specific cadherin,FLJ17376,OTTHUMP00000174777,type 2,type 2 (vascular endothelium),vascular endothelial,Vascular endothelial cadherin,Vascular epithelium cadherin,VE Cad,VE cadherin (vascular epithelium),VEC
- Application:
- IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human VE-Cadherin / CD144 Protein
- Clone:
- B103
- Uniprot:
- P33151
- Synonyms:
- 7B4;7B4 antigen;cadherin 5, type 2 (vascular endothelium);cadherin 5, type 2, VE-cadherin (vascular epithelium);cadherin-5;CD144;cd144 antigen;endothelial-specific cadherin;vascular endothelial cadherin;VE-cadherin
- Extra Details:
- Cadherins (Calcium dependent adhesion molecules) are a class of transmembrane proteins. Cadherin-5, also known as VE-cadherin, CDH5 and CD144, an endothelial specific cell-cell adhesion molecule, plays a pivotal role in the formation, maturation and remodeling of the vascular wall. VE-Cadherin is widely considered to be specific for vascular endothelia in which it is either the sole or the predominant cadherin, often co-existing with N-cadherin. This specificity of VE-cadherin for vascular endothelial cells is important not only in blood and lymph vessel biology and medicine, but also for cell-type-based diagnoses, notably those of metastatic tumors. As a classical cadherin, VE-Cadherin links endothelial cells together by homophilic interactions mediated by its extracellular part and associates intracellularly with the actin cytoskeleton via catenins. Mechanisms that regulate VE-cadherin-mediated adhesion are important for the control of vascular permeability and leukocyte extravasation. In addition to its adhesive functions, VE-Cadherin regulates various cellular processes such as cell proliferation and apoptosis and modulates vascular endothelial growth factor receptor functions. Consequently, VE-cadherin is essential during embryonic angiogenesis.
- Shipping Conditions:
- Blue Ice