AN300173P
Recombinant BLyS/TNFSF13B/BAFF Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300173P
- Additional Names:
- UNQ,PRO,ZTNF,TNF- and APOL-related leukocyte expressed ligand,TNFSF,TNFSF13B,BAFF,BLYS,CD257,DTL,TALL-1,TALL1,THANK,TNFSF20,TNLG7A,ZTNF4,Tumor necrosis factor ligand superfamily member 13B,B lymphocyte stimulator,B-cell-activating factor,Dendritic cell-derived TNF-like molecule,TNF- and APOL-related leukocyte expressed ligand 1,UNQ401,PRO738,BAFF,TNFSF13b,TALL-1,ApoL related ligand TALL 1,B cell Activating Factor,CD 257,CD257 antigen,Delta BAFF,Dendritic cell derived TNF like molecule,DTL
- Application:
- Flow Cytometry, WB, IP
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human BLyS / TNFSF13B / BAFF protein
- Clone:
- A1287
- Uniprot:
- Q9Y275
- Synonyms:
- ApoL related ligand TALL-1;B lymphocyte stimulator;B-cell-activating factor;B-lymphocyte stimulator;BAFF;BLYS;CD257;delta BAFF;Delta4 BAFF;dendritic cell-derived TNF-like molecule;DTL;epididymis secretory sperm binding protein;TALL-1;TALL1;THANK;TNF and ApoL-related leukocyte expressed ligand 1;TNF homolog that activates apoptosis;TNF- and APOL-related leukocyte expressed ligand 1;TNFSF20;TNLG7A;tumor necrosis factor (ligand) superfamily, member 13b;tumor necrosis factor (ligand) superfamily, member 20;tumor necrosis factor ligand 7A;tumor necrosis factor ligand superfamily member 13B;tumor necrosis factor superfamily member 13b;tumor necrosis factor-like protein ZTNF4;ZTNF4
- Extra Details:
- BAFF, a member of the TNF superfamily of proteins, is a homotrimeric transmembrane protein, which is cleaved to produce a soluble cytokine. BAFF may also further oligomerize into 60-mer structures. BAFF is expressed by monocytes, neutrophils, macrophages, dendritic cells, activated T cells, and epithelial cells. BAFF plays a key role in B cell development, survival, and activation. BAFF binds to three distinct receptors, BAFF-R, TACI, and BCMA. These receptors are differentially expressed during B cell development and among B cell subsets. While BAFF-R and BCMA bind to the homotrimeric form of BAFF, TACI only binds to membrane bound or higher order BAFF structures. The BAFF/ BAFF-R interaction activates both canonical and non-canonical NF-K KappaB pathways, PI3K/Akt, and mTOR. Activation of the noncanonical NF-K KappaB pathway via BAFF-R is negatively regulated by TRAF3. Research studies have shown that elevated levels of BAFF may exacerbate many autoimmune disorders, making it a potential therapeutic target.
- Shipping Conditions:
- Blue Ice