Recombinant CD302/CLEC13A Monoclonal Antibody

Size

£361.80

Was £402.00

SKU:: AN300166P
Additional Names:: 1110055L24Rik,AI159627,Clec13a,Cd302,DCL1
Application:: IHC-P
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Mouse
Buffer:: PBS
Immunogen:: Recombinant Mouse CD302 / CLEC13A protein
Clone:: A1280
Uniprot:: Q9DCG2
Synonyms:: 1110055L24Rik;AI159627;C-type lectin domain family 13 member A;CD302 antigen;type I transmembrane C-type lectin receptor DCL-1
Extra Details:: CD302/CLEC13A (C-type lectin domain family 13 member A), also known as C-type lectin receptor DCL-1, is a type I transmembrane C-type lectin DCL-1/CD302. DCL-1 protein was highly conserved among the human, mouse, and rat orthologs. DCL-1 ectodomain contains only one CRD, whereas other type I transmembrane C-type lectins contain more than one domain (e.g. selectins and MMR). DCL-1 CP contains several putative motifs, including a Tyr-based internalization, a cluster of acidic amino acids, and Ser and Tyr phosphorylation motifs, suggesting that DCL-1 CP mediates not only endocytosis and late endosome targeting but also signaling. DCL-1 may be another cell/matrix adhesion receptor integrated in cell adhesion complexes and that DCL-1 dysfunction may affect APC adhesion and migration, causing suppression of APC function.