AN300093P
Recombinant CD84/SLAMF5 Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300093P
- Additional Names:
- hCD,mCD,SLAM family member,Cell surface antigen MAX,Leukocyte differentiation antigen CD,Signaling lymphocytic activation molecule,SLAMF,Cell surface antigen MAX.3,hCD84,Hly9-beta,Leukocyte differentiation antigen CD84,LY9B,mCD84,Signaling lymphocytic activation molecule 5,SLAM family member 5,SLAMF5,CD84,GR6
- Application:
- WB, IP
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human CD84 protein
- Clone:
- A1207
- Uniprot:
- Q9UIB8
- Synonyms:
- CD84 antigen (leukocyte antigen);cell surface antigen MAX.3;hCD84;hly9-beta;leucocyte differentiation antigen CD84;leukocyte antigen CD84;leukocyte differentiation antigen CD84;LY9B;mCD84;signaling lymphocytic activation molecule 5;SLAM family member 5;SLAMF5
- Extra Details:
- The CD2 family receptors are type I transmembrane glycoproteins belonging to immunoglobulin (Ig) superfamily characterized by a membrane-proximal Ig constant 2 (C2) domain and a membrane-distal variable (V) domain that is responsible for ligand recognition. CD84, also known as LY9B and SLAMF5, is a homophilic member of the SLAM (signaling lymphocyte activation molecule) subfamily of the CD2 family. The SLAM family receptorsmediate signal transduction through the interaction of its ITSM (immunoreceptor tyrosine-based switch motifs) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. The CD84-CD84 interaction was independent of its cytoplasmic tail. Thus, CD84 is its own ligand and acts as a costimulatory molecule. CD84 is expressed on cells from almost all hematopoietic lineages and on CD34+ hematopoietic progenitor cells, suggesting that CD84 serves as a marker for committed hematopoietic progenitor cells.
- Shipping Conditions:
- Blue Ice