AN300055P
Recombinant NPC2 Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300055P
- Additional Names:
- NPC,HE1,NPC2,EDDM1,Epididymal protein 1,Epididymal secretory protein,Epididymal secretory protein E1,Human epididymis-specific protein 1,Niemann-Pick disease type C2,Niemann-Pick disease type C2 protein,NPC intracellular cholesterol transporter 2,Tissue specific secretory protein
- Application:
- IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- Recombinant Human NPC2 Protein
- Clone:
- A1165
- Uniprot:
- P61916
- Synonyms:
- EDDM1;epididymal protein 1;Epididymal secretory protein E1;epididymis secretory sperm binding protein;HE1;human epididymis-specific protein 1;Niemann-Pick disease type C2 protein;NPC intracellular cholesterol transporter 2;tissue-specific secretory protein
- Extra Details:
- Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.
- Shipping Conditions:
- Blue Ice