AN300032P
Recombinant Bcl-2 Monoclonal Antibody
Size
£361.80
Was £402.00
- SKU:
- AN300032P
- Additional Names:
- B-cell Lymphoma,PPP1R,BCL,Bcl-2,PPP1R50,BCL2,apoptosis regulator Bcl-2,B-cell Lymphoma 2,apoptosis regulator Bcl-2,Bcl-2,PPP1R50,Apoptosis regulator Bcl 2,Apoptosis regulator Bcl2,AW986256,B cell CLL/lymphoma 2,B cell leukemia/lymphoma 2,B-cell,C430015F12Rik,D630044D05Rik,D830018M01Rik,Leukemia/lymphoma,Oncogene B-cell leukemia 2,Protein phosphatase 1,regulatory subunit 50,Bcl2
- Application:
- Flow Cytometry, IHC-P
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C/-70[o]C Avoid freeze/thaw cycles., 2-8[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS
- Immunogen:
- A synthetic peptide corresponding to the N-terminus of the Human Bcl-2.
- Clone:
- A1142
- Uniprot:
- P10415
- Synonyms:
- apoptosis regulator Bcl-2;B-cell CLL/lymphoma 2;Bcl-2;PPP1R50;protein phosphatase 1, regulatory subunit 50
- Extra Details:
- Bcl-2 is a member of a family of proteins that regulates outer mitochondrial membrane permeability. Bcl-2 is an anti-apoptotic member that prevents release of cytochrome c from the mitochondria intermembrane space into the cytosol. Bcl-2 is present on the outer mitochondrial membrane and is also found on other membranes in some cell types. Natural Bcl-2 contains a carboxyl-terminal mitochondria targeting sequence. Recombinant Bcl-2, missing the mitochondrial targeting sequence, maintains its ability to neutralize pro-apoptotic Bcl-2 family members. Neutralization by Bcl-2 appears to be through binding the BH3 region of pro-apoptotic Bcl-2 family members. This activity does not require the mitochondrial targeting sequence.
- Shipping Conditions:
- Blue Ice